Singapore 2012 Program


Metabolism of Cell Death and its Ramifications for Therapeutics and Drug Development


  Conference location: National University of Singapore, Singapore

June 29-July 1, 2012

Shazib Pervaiz, Richard Lockshin, and Zahra Zakeri

Friday June 29th 12:00pm – 5:00pm:

Welcome Introduction and awards  

Chair: Zahra Zakeri, Dept. of Biology, Queens College of CUNY, USA 

12:00-12:15pm           Introduction and welcome 

Zahra Zakeri: Queens College, U.S.A.

12:15-12:45pm           Presenting Award to Dr. Kimchi

Richard A. Lockshin: St. Johns University, U.S.A 

12:45-1:45pm              Programmed cell death: from single gene studies towards global network analysis

Adi Kimchi: Weizmann Inst., Israel

1:45-2:15pm               The hows and whys of IAPs as revealed by multi-gene deletions and SMAC-mimetics

David Vaux: WEHI Institute and LaTrobe University, Australia

2:15-2:30pm               Coffee

2:30-3:00pm               Regulation of apoptosis signaling by the outer mitochondrial membrane protein MOAP-1 and Bax-beta
Victor C Yu: National University of Singapore, Singapore

3:00-3:30pm               BID stimulates the ATR-directed DNA damage response to replicative stress to maintain hematopoietic stem and progenitor cell function- insights into maintenance of hematopoietic stem cell function in aging organisms 
Sandra Zinkel: Vanderbilt University School of Medicine, USA

3:30-4:00pm               Exposure of phosphatidylserine to the cell surface

Shigekazu Nagata: Kyoto University, Japan

4:00-4:30 pm              TAM Receptors Control Phagocytosis of Apoptotic Cells
Raymond Birge: Univ. Med. Dent. New Jersey, USA 

4:30-4:45 pm                    Activation of Lysosomal Function in the Course of Autophagy via mTORC1 Suppression and Autophagosome-Lysosome Fusion

Han-Ming Shen, National University of Singapore

4:45-5:00pm                Novel function and age-dependent changes of the ubiquitin system in selective autophagy

Esther WongNanyang Technological University, Singapore

Saturday June 30th 9:00am –5:PM


Cell death Metabolism: Redox and Energetics

Chair: Simone Fulda: Univ. of Ulm, Germany

9:00-9:30am               intracellular redox status and cell fate regulation by the Bcl-2 family
Shazib Pervaiz:
National University of Singapore, Singapore

9:30-10:00am             Metabolic vulnerabilities and cancer cell death. 

David Hockenbery Fred Huntchinson Cancer Research Center USA

10:00-10:30am           Ongogene driven redox cell survival mechanisms'

Thomas G Cotter University College Cork Ireland

10:30-11:00am           Coffee Break

11:00-11:30am           Effect of ceramide depletion on cellular bioenergetics, survival, and autophagy

Scott A. Summers:  Duke-National University of Singapore, Singapore

11:30-11:45am           XF Mito Stress Test reveals metabolic dysfunctions underlying cellular degeneration and guides translational studies

David A. Ferrick: Chief Scientific Officer, Seahorse Bioscience

11:45- 12:00pm          Identification of gamma-tocotrienol as a novel chemosensitizer in xenograft mouse model of human gastric cancer

Gautam Sethi  National University of Singapore, Singapore

12:00-2:00pm             Lunch and poster presentation and WORKSHOP OF INDUSTRY OR TRANSLATIONAL IMPLICATION

Chair: Marianne J Cronje: Univ. Johannesburg, South Africa

2:00-2:30pm               Revisiting the pathways activated upon the induction of intracellular redox imbalance and their role in tumorigenesis and tumor cells’ resistance to chemotherapy

Marie-Veronique Clement: National University of Singapore, Singapore

2:30-3:00pm               Unfolding the role of ROS-mediated ER stress in immunogenic apoptosis of cancer cells

Patrizia Agostinis: University of Leuven Belgium

3:00- 3:30pm              Targeting IAP proteins for tumor cell sensitization to cell death         
Simone Fulda:Univ. of Ulm, Germany

3:30-5:00pm               Coffee:  and WORKSHOP ON BUILDING A CAREER IN SCIENCE : Panel Discussion on Tactics for Junior Scientists and Women. Panelists Patrizia Agostinis, Marie-Veronique Clement; Adi Kimchi; Sandra Zinkel, Ana Maria Cuervo, Devrim Gozuacik, Boris Zhivotovsky, Simone Fulda

Saturday July 1 th 9:00am – 5:00pm

Role of autophagy & apoptosis in metabolic health and aging

Chair: Raymond Birge: Univ. Med. Dent. New Jersey, USA Chair:

9:00-9:30am               Discovery of new autophagy regulators

Devrim Gozuacik: Sabanci University, Turkey

9:30-10:00am             Selective autophagy in aging and age-related pathologies

Ana Maria Cuervo, Einstein Medical College, USA

10:00-10:15am           Secreted frizzled-related protein 4 expression is positively associated with responsiveness to cisplatin of ovarian cancer cell lines in vitro and with lower tumour grade in mucinous ovarian cancers.

                                    Arun Dharmarajan, The University of Western Australia, Western Australia

10:15-10:30am           Age-dependent relationships between reactive oxygen species and hsp70 in human neutrophils under cell stress conditions.

Kovalenko E.I., - Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia

10:30-11:00am           Coffee Break

Chair: Nader Maghsoudi: Shahid Beheshti University, Iran 

11:00-11:30am           Inhibition of prenyl protein carboxylmethylation induces autophagic cell death

Mei Wang: National University of Singapore, Singapore

11:30-12:00am           Lung cancer: mechanisms of resistance and sensitivity to treatment.

Boris Zhivotovsky: Karolinska Institute, Sweden

12:00-2:00pm             Lunch and Posters and WORKSHOP OF INDUSTRY OR TRANSLATIONAL IMPLICATION  (2nd round)

Chair: Shazib Pervaiz:National University of Singapore, Singapore

2:00-2:30pm               The serendipitous discovery of the selective apoptotic-inducing abilities of novel metal phosphine compounds in cancer cells

Marianne J Cronje, Univ. Johannesburg, South Africa

2:30-3:00pm               Regulation of cellular survival by p53 and p73 – implications for cancer therapy

Kanaga Sabapathy: National University of Singapore, Singapore

3:00--3:30pm              Future Anti-Cancer Therapeutic Targets: Putting the Carts Before the Horses?               
Tak Mak, Advanced Medical Discovery Unit, University of Toronto, Canada

3:30-4:00pm   Coffee

4:00-4:30pm               Therapeutic targeting Myc dependency in cancer cells: new pathway implicated in tumorigenesis and targeted therapy.

Yu Qiang: National University of Singapore, Singapore

4:30-4:45pm               The mechanism by which a novel palladacycle aj-5 exerts its anti-tumour activity in breast cancer cells involves apoptosis and autophagy
Aliwaini S* University of Cape Town.

4:45-5:00pm               Closing remarks:  Zahra Zakeri