Brazil 2011 Program

Tentative Program (04-27-2011)

Signaling in cell death survival, proliferation and degeneration

Conference location:São Paulo Brazil

June-10-13, 2011


Soraya Smaili, Sergio Lavandero, Richard Lockshin, Roya Khosravi-Far and Zahra Zakeri

 June 10th 2:00pm – 6:00pm:

Signaling in cell death survival, proliferation and degeneration

Conference location:  São Paulo Brazil

June-10-13, 2011


Soraya Smaili, Sergio Lavandero, Richard Lockshin, Roya Khosravi-Far and Zahra Zakeri


June 10th 2:00pm – 6:00pm:


Welcome Introduction and awards  

Chair: Zahra Zakeri, Dept. of Biology, Queens College of CUNY, USA 

2:00-2:15pm                  Introduction and welcome 

Zahra Zakeri: Queens College, U.S.A.


2:15-2:30pm                  Presenting Award to Dr. Guido Kroemer 

Richard A. Lockshin: St. Johns University, U.S.A 

2:30-3:30pm                  Cancer cell death; killing the immortal 

Guido Kroemer. Institut Gustave Roussy, France


3:30-4:00pm                  Coffee Break

Pathways to cell death and cell survival 

Chair: Marie-Lise Gougeon, Institut Pasteur, France


4:00-4:30pm                  Integration of glucose metabolism and apoptosis by the BCL-2 family protein BAD 

Nika Danial, Dept. of Pathology, Harvard University, USA

4:30-5:00pm                  New functions of the BCL-2 protein family on ER physiology 

Claudio Hetz, Inst. of Biomedical Sciences, Univ. of Chile, Chile

5:00-5:30pm                  Physiological mechanisms mediated by the prion protein in the control of cell death and survival 

Rafael Linden, Instituto de Biofisica da UFRJ, Brazil


5:30-5:45pm                  Increased ER-mitochondrial coupling stimulates mitochondrial metabolism during early stages of ER stress.

Roberto Bravo, Univ. Chile, Santiago, Chile


5:45-6:00pm                  Analysis of apoptosis regulatory genes controlled by histone deacetylase inhibitors in chronic lymphocytic leukemia cells,

Joan Gil, University of Barcelona-IDIBELL, Spain

7:00pm             Social hour Dinner 


June 11th 9:00am – 7:30pm


Regulation of cell death in cancer I  

Chair: Marianne J Cronje, Univ. Johannesburg, South Africa 

9:00-9:30am               Desirable off-target effects of anticancer agents

Laurence Zitvogel, INSERM and Institut Gustave Roussy, Villejuif, France

9:30-10:00am               Sensitivity and resistance in preclinical cancer model

Klaus-Michel Debatin, Children’s Cancer Center, Ulm, Germany

10:00-10:30am             Novel cell death regulatory pathways in cancer

Gustavo Amarante Mendes, Universidade de São Paulo, São Paulo, Brazil


10:30-11:00am Coffee Break


Regulation of cell death in cancer II  

Chair:  Katharina D'Herde, Dept. Human Anatomy and Embryology, Fac. Medicine, Univ. Gent, Belgium

11:00-11:30am           Cell death pathways to cancer 

Roya Khosravi-Far, Dept. of Pathology, Harvard U. Med. School, USA

11:30-12:00am           A dual role for galectin-3 in cell death within specialized tissue microenvironment

Roger Chammas – University of São Paulo, Brazil

12:00-12:15pm           Enhancement of TRAIL-induced apoptosis by Homoharringtonine in human colon cancer cells

                                 Jarmila Stremenova-- Charles University in Prague, Prague, Czech Republic

12:15-12:30pm           MicroRNA-10b is down-regulated in head and neck cancer and could impact cancer development through kfl4 signaling

Flavia Maziero Andreghetto, Albert Einstein Research and Education Institute, São Paulo, Brazil

12:30-2:00pm             Lunch


Regulation of cell death in cancer III  

Chair: Andrew Quest, University of Chile, Chile

2:00-2:30pm               Exploiting cell death signaling pathways to overcome cancer resistance

Simone Fulda. Institute for Experimental Cancer Research in Pediatrics, Goethe-University Frankfurt

2:30-3:00pm               Redox regulation of cell fate in cancer cells 

Shazib Pervaiz, National University Health System, Singapore

3:00-3:30pm                  The p53 family between development, cell death and cancer

Gerry Melino, Univ. di Roma ‘Tor Vergata’, Italy and MRC, Univ. of Leicester, UK – Not confirmed by registration

3:30-4:00pm      Coffee

Regulation of Death in Neurodegeneration and Neuroprotection I

Chair: Maria de Fatima Leite, Federal University of Minas Gerais, Brazil


4:00-4:30pm               The prion protein as a survival target in Alzheimer’s disease 

                                 Vilma Martins – Cancer Hospital, São Paulo, Brazil


4:30-5:00pm               S100B releasing as a signal of astrocyte activation to survival or death

Carlos Alberto S. Gonçalves – Federal University of Minas Gerais  Brazil

5:00–5:15am              Study of calcium signalling in a rat model of sporadic Alzheimer's Disease

                                 Leticia Rodrigues,  Federal University of São Paulo


5:15–5:30am              p53 protein directly regulates the mitochondrial PTP pore during oxidative stress-induced necrosis and ischemic stroke

                                 Ute Moll – Dept. of Pathology, Stony Brook University, Stony Brook NY

5:30-7:30pm   Poster Session

8:00pm                      Dinner

June 12th 9:00am – 7:30pm


Regulation of Death  

Chair: Sergio Lavandero, Univ. of Chile School of Medicine, Santiago,Chile


9:00-9:30am   Role of TRPM4 in cell death 

Andres Stutzin, Univ. of Chile, Santiago, Chile

9:30-10:00am             Prostate epithelial cell apoptosis: new approaches to an old model

                                    Hernandes Carvalho – University of Campinas, São Paulo, Brazil


10:00-10:15                A natural cytotoxic peptide from the venom of South American rattlesnake targets tumor cells in vivo, triggers cell death by calcium-dependent pathway and shows significant efficacy in melanoma tumor in vivo model

Mirian Hayashi,  Universidade Federal de São Paulo (UNIFESP) 


10:15-10:30am           Apoptotic and non-apoptotic roles of caspases in embryonic tooth-bone complex formation

Eva Matalová, Czech Academy of Sciences Prague, Czech Republic 

10:30-11:00am           Coffee Break

Regulation of Death  

Chair:  Nader Maghsoudi, Neuroscience Research Center, Shahid Beheshti University of Medical Science, Tehran, Iran

11:00-11:30am           The survivin/Cox2 connection to tumor suppression by caveolin 1

Andrew Quest, University of Chile, Chile

11:30-12:00pm           Intracellular pathogens and cell death 

Marisa Isabel Colombo, Universidad Nacional de Cuyo - Mendoza - Argentina 


12:00-12:15pm           Combining cell death and immune stimulation using p19Arf and IFNb in a B16F10 tumor vaccine model

Ruan Medrano, InCor HCFM-USP, São Paulo, Brazil



12:15-12:30pm           Overcoming tumor and virus strategies to keep cells alive: translation of mouse models into a human disease

Julian Pardo, Univ. of Zaragoza, Spain

12:30-2:00pm             Lunch


Young scientist Mentoring Workshop:  How the young scientists in the field can survive, network and excel. 

Moderator: Zahra Zakeri, Dept. of Biology, Queens College of CUNY, USA 

2:15- 2:45pm              What are the obstacles holding back scientists?

                                 Soraya  Smaili, Departamento de Farmacologia, Universidade Federal de São Paulo (UNIFESP/EPM), São Paulo, SP, Brazil.


2:45- 3:45pm Panel discussion:


Panelists:  Roya Khosravi-Far; Marie-Lise Gougeon; Guido Kroemer ; Simone Fulda; Eileen White; Marianne J Cronje; Soraya  Smaili; Marisa Isabel Colombo,  Gerry Melino, Simone Fulda


Regulation of Death  

Chair: Simone Fulda, Institute for Experimental Cancer Research in Pediatrics, Goethe-University Frankfurt

4:00-4:30pm               Double stranded DNA virus tools to cope with cell stress and death

Covadonga Alonso: Dpt. Biotecnologia, Universidad Autónoma de Madrid, Spain

4:30-5:00pm               TAM Receptors in Immune Modulation and Clearance of Apoptotic Cells

Raymond Birge: UMDNJ-New Jersey Medical School, Newark, NJ USA

5:00–5:15am              Flavivirus NS4A-induced autophagy protects cells against death and enhances virus replication

                                 Emmanuel Datan, Queens College of CUNY, New York, NY USA


5:15–5:30am              Dengue virus infection upregulates cell death markers in human monocytes and caspase inhibitor modulates virus load

                                 Amanda Torrentes-Carvalho,  Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro


5:30-7:30pm               Poster Session

8:00pm                      Dinner

June 13th 9:00am – 2:00pm


Targeting autophagic cell death pathways

Chair: Mauro Piacentini, National Institute for Infectious Diseases IRCCS L. Spallanzani, and Univ. de Roma “Tor Vergata”, Rome, Italy

9:00-9:30am                  The role of bec-1 in C. elegans development and aging

Alicia Melendez Queens College, U.S.A.


9:30-10:00am                Role of Ambra1 in autophagy regulation: far beyond Beclin 1 interaction

Gian Maria Fimia, National Institute for Infectious Diseases IRCCS L. Spallanzani, Rome, Italy

10:00–10:15am             The role pf MKP-1 in autophagy and apoptosis during ischaemia/reperfusion injury in the heart

Anna-Mart Engelbrecht- Stellenbosch University, Stellenbosch, South Africa

10:15–10:30am             The dual PI3K/mTOR inhibitor NVP-BEZ235 and chloroquine synergize to trigger apoptosis through lysosomal membrane permeabilisation in neuroblastoma cells

                                    Christian Seitz, Goethe-University Frankfurt am Main,Germany


10:30-11:00am Coffee

Pathways to cell death and cell survival II

Chair: Soraya Smaili, Departamento de Farmacologia, Universidade Federal de São Paulo (UNIFESP/EPM), São Paulo, SP, Brazil.


11:00-11:30am             DOR: a new regulator of autophagy

Antonio Zorzano, Institute for Research in Biomedicine (IRB Barcelona), Spain       

11:30-12:00pm Wrap up

Richard Lockshin, St. John’s Univ., Jamaica NY, USA  


12:00-2:00pm                Lunch and End of Meeting