Maynooth Announcement

The Fifth International Cell Death

Richard Lockshin -1416414211


The Fifth International Cell Death

Society Symposium

Maynooth, Ireland 2004


Friday 25th June 2004


Time                                              Session, Topic


11:00 am-7:00 pm                        Delegate Registration (HumeBuilding, North Campus)



I. Welcome and Introduction


2:00-2:30pm                                 Zahra Zakeri

                                                      Queens College, City University of New York, U.S.A. 


II. Modulators of cell death and cell survival

Chair: Junying Yuan


2:30-3:00 pm                                Chemical Definition of a Novel Cell Death Pathway
Junying Yuan:
Harvard Medical School, U.S.A.


3:00-3:30 pm                                Bad integrates glycolysis & apoptosis through a mitochodrial macromolecular complex with glucokinase

                                                      Nika Danial: Howard Hughes Medical Institute, U.S.A 


3:30-4:00 pm                                Role of the BH3-Only protein BIM in diseases

                                                      Philippe Bouillet: WEHI, Australia


4:00-4:30pm                                 Effectors and inhibitors of Bcl-2 family proteins on mitochondria and the ER

                                                      Christoph Borner: Institute of Molecular Medicine& Cell Research, Germany 


4:30-5:00pm                                 Coffee


5:00-5:30pm                                 IGF-1 survival signaling in tumor cells

                                                      Rosemary O’Connor: National University of Ireland, Ireland 


5:30-6:00pm                                 Bax-induced calcium release and wave propagation in cell death

                                                      Soraya Smaili: Federal University of Sao Paulo, Brazil.


6:00-6:20pm                                 LEDGF: a novel modulator of cell death and survival in the face of stress

                                                      Carlos Casiano: Loma Linda University School of Medicine, U.S.A. 


6:20-6:40                                      The roles of BID in apoptosis

                                                      Atan Gross: Weizmann Institute, Israel 


7:00pm-10:00pm                          Welcome reception (hot buffet, Pugin Hall)


Saturday 26th June 2004


III. Paths to destruction—Receptor driven pathways

Chair: Roya Khosravi-Far


9:00-9:30am                                 Studies from Fas to the engulfment of apoptotic cells

                                                      Shigekazu Nagata: Osaka University Medical School, Japan.


9:30-10:00am                               CD95 (Apo-1/FAS) signaling pathways and diseases

                                                      Peter Krammer: German Cancer Research Center, Germany


10:00-10:30am                             TRAIL-induced signaling and apoptosis

                                                      Marion Macfarlane: University of Leicester, U.K


10:30-10:50am                             The Mer tyrosine kinase (Mertk) provides ‘enhancing signals’ for abb5-integrin-mediated phagocytosis of apoptotic cells
Raymond Birge: UMDNJ-New Jersey Medical School, U.S.A


10:50-11:20am                             Coffee


11:20-11:50am                             The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress

                                                      Jurg Tschopp: University of Lausanne, Switzerland:


11:50-12:20                                  Molecular switches and spatial control of cell death in neurons

                                                      Pierluigi Nicotera: University of Leicester, U.K


12:20-12:50am                             Mechanisms controlling sensitivity and resistance to TRAIL.

                                                      Henning Walczak: German Cancer Research Center, Germany


12:50-1:10pm 40pm                     Regulation of divergent cell death pathways by Bcr-Abl

                                                      Gustavo Amarante-Mendes: University of Sao Paulo, Brazil


12:40-1:1000pm                           Mechanisms controlling sensitivity and resistance to TRAIL.

                                                      Henning Walczak: German Cancer Research Center, Germany 


1:00-2:15pm                                 Lunch




IV. Paths to destruction—Intracellular Pathways

Chair: Michael Hengartner


2:15-2:45pm                                 Cell death pathways in cancer

                                                      Yuri Lazebnik: Cold Spring Harbor Laboratory, U.S.A 


2:45-3:15pm                                 The dual role of Omi/HtrA2 in survival and death

                                                      Emad AlnemriThomas Jefferson Univ., U.S.A.


3:15-3:45pm                                 Monitoring mitochondrial and post-mitochondrial death signals in real time

                                                      Jochen Prehn: Royal College of Surgeons in Ireland, Ireland 


3:45-4:15pm                                 Coffee


4:15-4:45pm                                 Bcl-Xl can repair apoptotic permeability of the mitochondrial outer membrane in vitro

                                                      Ruth Kluck: Walter & Eliza Hall Institute of Medical Research, Australia 


4:45-5:05pm                                 Die another way!

                                                      Afshin Samali: National University of Ireland, Ireland


5:05-5:25pm                                 The BH3 domain protein BNIP3 provokes mitochondrial defects and hypoxia-mediated cell death of ventricular myocytes

                                                      Lorie Kirshenbaum: University of Manitoba, Canada


5:30-pm                                         Poster session


7:30pm                                          Dinner (Pugin Hall, South Campus) followed by Social Event.


Sunday 27th June 2004


V. Agents of destruction (caspases, cathepsins, granzymes)

Chair: Raymond Birge


9:00-9:30am                                 Cellular and therapeutic aspects of caspase modulation

                                                      Don Nicholson: Merck Research Laboratories, U.S.A


9:30-10:00am                Transcriptional Regulation of Caspase activation in  Drosophila
                           Sharad Kumar: Hanson Institute, Australia 

10:00-10:30am                             Granzyme A directly triggers mitochondrial damage (without apoptogenic factor release) that is necessary for apoptosis induction

                                                      Judy Lieberman: The CBR Inst. For Biomedical Research, Harvard Medical School, U.S.A


10:30-11:00am                             Coffee


11:00-11:30am                             Identification of novel substrates of the CTL/NK protease Granzyme

                                                      Seamus Martin:  Trinity College Dublin, Ireland 


11:30-12:00am                             Caspase activation inhibits proteasome function during apoptosis
Gerry Cohen:
University of Leicester, U.K


12:00-12:30am                             Expanding roles for the apoptosome in development and diseases

                                                      Francesco Cecconi: University of Rome “Tor Vergata”, Italy


12:30-1:00pm                               Lysosomal control of tumor cell death

                                                      Marja Jättellä: Institute of CancerBiology, Denmark


1:00-2:30pm                                 Lunch


VI. Sensing and Responding to Damage

Chair: Hans-Uwe Simon


2:30-3:00pm                                 Molecular networks in programmed cell death: DAP genes and beyond

                                                      Adi Kimchi: Weizmann Institute, Israel 


3:00-3:30pm                                 BRCA1- A differential modulator of chemotherapy induced apoptosis

                                                      Paul Harkin: Belfast City Hospital, N. Ireland


3:30-3:50pm                                 Actin cytoskeleton network as a modulator of apoptosis and phagocytic activity in metastatic melanoma cells

                                                      Walter Malorni: Istituto Superiore di Sanita, Italy


3:50-4:20pm                                 Coffee


4:20-4:50pm                                 Regulating the apoptotic function of p53 by the ASPP family of proteins

                                                      Xin Lu: ImperialCollegeLondon, England


4:50-5:20pm                                 Cell Cycle Proteins in the Neuronal response to Neurodegenerative Stimuli

                                                      Kelly Jordan: University of Pennsylvania School of Dentistry, U.S.A. 


5:20-pm                                         Poster session


7:30pm                                          Meeting Dinner (Pugin Hall) Introductory Presentation Richard A. Lockshin

                                                      Honoring Prof. Krammer and Prof. Nagata


Monday 28th June 2004


VII. Apoptosis in Action (Animal models, Immunity & Disease)

Chair: Amedeo Colombano


9:00-9:30am                                 Cell death in the eye: A model for disease and development  

                                                      Tom Cotter: University College Cork, Ireland 


9:30-10:00am                               Regulation of death ligand-induced apoptosis in immunopathology

                                                      Thomi Brunner: University of Bern, Switzerland


10:00-10:30am                             Transglutaminase 2 regulates the mitochondrial respiratory complexes assembly in vivo through its protein disulphide isomerase activity

                                                      Mauro Piacentini: University of Rome “Tor Vergata”, Italy


10:30-10:50am                             Modulation of prostate tumor cells response to radiation

                                                      Adrianna Haimovitz-Friedman: Memorial Sloan Kettering Cancer Center, USA 


10:50-11:20am                             Coffee


11:20-11:50am                             The NOD family of proteins: Role in innate immunity and inflammatory disease

                                                      Gabriel Nuñez: University of Michigan Medical School, USA 


11:50-12:10am                             Presence of functional extrinsic and intrinsic apoptotic pathways in human mesenchymal stem cells 

                                                      Huseyin Mehmet: Imperial College London Hammersmith Hospital Campus, U.K 


12:10-12:30am                             Identification of proteins regulating p73 function     Vincenzo De Laurenzi: MRC Toxicology Unit, U.K


12:30-1:00pm                               Wrap-Up

                                                      Boris Zhivotovsky: Karolinska Institutet, Sweden 


1:00-2:15pm                                 Lunch and End of Meeting